Three Important Findings From This Study - 1414 Words

BIOCHEM 2B03 Inquiry Paper Group 30 1.Provide a summary of three important findings from this study (3 marks). Also discuss the importance/novelty of the major finding as it pertains to the field (3 marks). Use a maximum of half a page for your answer.(6 marks total) The authors of this study found that leukemia stem cell (LSC) self-renewal can be prevented through the inhibition of JAK2 and BCR-ABL1 which reduces ADAR1 expression. Furthermore, the addition of JAK2 expression further enhanced potentiated A-to-I RNA editing, whereas selective JAK2 inhibition was found to reverse RNA editing activity in K562 cells. It was also concluded that ADAR1 regulates let-7 miRNA biogenesis, which impacts the self-renewal of progenitors. These major†¦show more content†¦The binding of a miRNA to this complementary sequence decreases translation of the target mRNA (3). D. A-to-I editing Adenosine-to-inosine RNA editing Promotes cancer progression and therapeutic resistance by contributing to LSC self-renewal Activated by JAK2 signaling E. LIN28b/Let-7 axis The expression of let-7 family is required for developmental timing and tumour suppressor function, but must be suppressed for the self-renewal of stem cells (3). Biogenesis of let-7 is regulated by LIN28b (3). Findings in the article suggest that JAK2 signaling â€Å"increases LIN28B pluripotency gene expression and inhibit the expression of let-7 family miRNAs† (3). 3. List the steps involved in the generation of the human JAK2-GFP lentiviral construct and the production of viral particles from this. Create a schematic to help illustrate your explanation. Also discuss how the authors used this tool to test their question and the limitations of the technique. Outline alternatives of this system for introducing transgenes and discuss the advantages and disadvantages of these approaches. (1 mark for definition/what is studied by the technique, 1 mark for listing steps involved, 1 mark for limitations, 2 marks for alternatives, 3 marks for advantages/disadvantages, total 8 marks) In order to determine how JAK2 signaling directly contribute to the activation of ADAR1 expression andShow MoreRelatedThe Factors That Affect The Learning Process Of L2 Words945 Words   |  4 Pages Studies which support the effect of cognateness: I shall present three studies in which their findings are incompatible with Milton and Daller’s (2007) findings, which disputed the impact of cognateness on L2 word learning. The first study was carried out by Willis Ohashi (2012) to investigate the factors that affect the learning process of L2 words. 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